Current Issue : January - March Volume : 2021 Issue Number : 1 Articles : 6 Articles
Background: Fulminant type 1 diabetes mellitus (FT1D) is a newly established subtype of type 1 diabetes. Its\netiology has not been fully elucidated. Several cases with FT1D have exhibited pancreatitis or myocarditis.\nCase presentation: We report a 31-year-old Japanese woman who showed upper abdominal pain and was\nadmitted to a local hospital. She was initially diagnosed with acute pancreatitis based on serum amylase elevation\nand swelling of the pancreas on computed tomography. Four days after admission, she developed diabetic\nketoacidosis and was transferred to our hospital. Her symptoms and laboratory findings met the FT1D criteria. On\nthe 3rd hospital day, electrocardiography (ECG) showed ST-segment elevation, and serum cardiac enzymes were\nmarkedly elevated. Because she exhibited late gadolinium enhancement in the apical wall on contrast-enhanced\ncardiac magnetic resonance imaging, she was diagnosed as acute myocarditis. Abnormal ECG findings and\nelevations of biomarkers associated with myocarditis showed improvement on the next day.\nConclusions: This is the first case of FT1D accompanied by both pancreatitis and myocarditis and suggests that the\npathophysiology of FT1D is related to the common etiology of acute pancreatitis and myocarditis....
Background: Gravesâ?? disease is the commonest cause of thyrotoxicosis whilst thyrotropin (TSH)-producing pituitary\nadenomas (thyrotropinomas, TSHomas) are very rare and account for just 1-2% of all pituitary adenomas. Coexistence\nof a TSHoma and Gravesâ?? disease has been very rarely reported. Here, we report a case of a patient whose initial\npresentation with primary thyrotoxicosis due to Gravesâ?? disease, was subsequently followed by a relapse of\nthyrotoxicosis due to a probable TSHoma.........................
Background: Acromegaly is a rare, chronic and severe disease. Drug therapy including somatostatin analogues\n(SAs), dopamine receptor agonists and growth hormone receptor antagonists (pegvisomant, PEG) are commonly\nused to treat patients who do not respond to surgery. The use of combination therapy with PEG and SAs has\nbecome more common over the last decade. We performed this study to accurately evaluate the effect of\ncombination therapy of SAs with PEG on acromegalic patients.\nMethods: PubMed, EMBASE, The Cochrane Library, ClinicalTrials.gov, Scopus, Web of Science, Chinese Biomedical\nLiterature Database and Trip database were searched for relevant studies. Prospective clinical trials treating\nacromegaly with the co-administration of SAs and PEG were included. We performed a meta-analysis by using\nStata 12.1. Sensitivity analysis was conducted to explore heterogeneity.............................
Background: Euthyroid sick syndrome (ESS) frequently arises in children admitted with diabetic ketoacidosis/\ndiabetic ketosis (DKA/DK). This study evaluates the interplay of various metabolic factors with occurrence of\nderanged thyroid function tests in children suffering from DKA/DK.\nMethods: 98 DKA and 96 DK pediatric patients were selected from hospital records. Those on thyroxine\nreplacement, with overt hypothyroidism, or with positive anti-thyroperoxidase (TPO) antibody were excluded. Tests\nfor liver function, renal function, lipid profile, serum osmolarity, thyroid function, c-peptide levels, and glycosylated\nhemoglobin were done on all patients. Children were divided into euthyroid (n = 88) and ESS groups (n = 106)................................
There is inconsistency in the literature regarding the management of women diagnosed\nwith subclinical hypothyroidism (SCH) during pregnancy in the postpartum period. The purpose of\nour study was to assess the need for continuation of levothyroxine (LT4) treatment after delivery.\nWe conducted a retrospective cohort study of 114 women with new-onset SCH during pregnancy and\nat 1-year follow-up postpartum. Criteria for continuation of LT4 after delivery were breastfeeding,\nthyrotropin (TSH) levels at diagnosis....................................
Background: We aimed to investigate the correlation of factors involved in the change of Mini-Mental State\nExamination (MMSE) and type 2 diabetes in the elderly.\nMethods: This study was a secondary analysis of a prospective cohort study. Type 2 diabetes patients aged > 55\nyears were recruited and assigned into three groups based on their glycated hemoglobin (HbA1c)............................
Loading....